A Dual‐Function Electrospun Matrix for the Prevention of Herpes Simplex Virus‐1 Infections after Corneal Transplantation

Tissue transplantations are often associated with severe infections. Cornea replacement as the most frequent transplantation worldwide bears risk of keratitis caused by herpes simplex virus (HSV), posing a and sight-threatening complication. To overcome current lack effective HSV therapy in eye, biodegradable nanofibrous scaffolds incorporating acyclovir (ACV) intended for along cornea graft to prevent viral infections designed. The rational development these matrices reveals strong dependency surface wettability on release kinetics tested biocompatible poly(lactic-co-glycolic acid) (PLGA) polymers. Using mixture two PLGA polymers, tailor-made antiviral active ACV is achieved treatment period. In human vitro infection model, synergistic inhibition mechanism binding particles fibers surface, while simultaneously releasing active, could be confirmed. Besides controlled release, polymer bind their significantly reducing titer. Based this tunable dual effect, fiber exhibit promising drug delivery platform, which can limitations transplantation.